The Science
Technology validated by first principles.
Three converging technology shifts make continuous musculoskeletal biomarker monitoring possible for the first time.
Microneedle ISF Access
Painless, sustained sampling at 1–2mm depth. Continuous analyte capture from interstitial fluid without venipuncture — real-time telemetry, not snapshots.
Electrochemical Biosensors
Clinical-grade sensitivity for proteins and ions in compact, low-power formats. Electrochemical immunosensing, aptamer-based detection, and ion-selective electrodes on a single chip.
Longitudinal AI/ML
Time-series modeling converts continuous biosignals into predictive clinical insights. Gradient Boosting for fracture risk, RNNs for flare prediction, and personalized therapy optimization.
Proprietary Algorithms
The AI forecasting engine.
Continuous telemetry powers predictive models that are simply impossible with episodic clinical snapshots. Our models learn your baseline over time to detect shifts before symptoms occur.
Time-series CTX-1/P1NP data combined with patient covariates feed a Gradient Boosting Machine that outputs a continuously updated fracture probability and projected BMD trajectory — replacing the static FRAX model.
How It Works
Mechanism of action.
Patch adheres
Painless application to skin surface
ISF access
Microneedles reach 2mm into interstitial fluid
Continuous sampling
Analytes captured in real-time
Equilibration
ISF ↔ blood correlation in 5–30 min
Live data
Biomarkers streamed to app and clinician
Interstitial fluid equilibrates with blood within 5–30 minutes, enabling near-real-time tracking of bone resorption, formation, mineral balance, and inflammation — without a single blood draw.
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